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FGFR2 polyclonal antibody
- カタログ番号 # : PAB12327
- 頻繁に訪問する :
- サイズ
- 価格
- 在庫あ
- 入手可能
- カート
- 100 ug
- JPY ¥ 39,000
- order now, ship in 5 days
-
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- この価格は、 Japanでのみ有効です。国を選択して下さい。
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Phone : +886-2-87511888
Fax : +886-2-87511166- 製品は、お客様に直接出荷されます。
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of FGFR2.
- Immunogen:
- A synthetic peptide corresponding to amino acids at C-terminus of human FGFR2.
- Host:
- Rabbit
- Theoretical MW (kDa):
- 92
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- Identical to the related rat and mouse sequence.
- Form:
- Lyophilized
- Purification:
- Affinity purification
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Western Blot (1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2 ug/mL)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
- Storage Instruction:
- Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development.
Arman E, Haffner-Krausz R, Chen Y, Heath JK, Lonai P.Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5082-7.
- 2.
- Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction.
Xu X, Weinstein M, Li C, Naski M, Cohen RI, Ornitz DM, Leder P, Deng C.Development. 1998 Feb;125(4):753-65.
- Entrez GeneID:
- 2263
- Gene Name:
- FGFR2
- Gene Alias:
- BEK,BFR-1,CD332,CEK3,CFD1,ECT1,FLJ98662,JWS,K-SAM,KGFR,TK14,TK25
- Gene Description:
- fibroblast growth factor receptor 2
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq
- Other Designations:
- BEK fibroblast growth factor receptor,FGF receptor,OTTHUMP00000020621,OTTHUMP00000020629,bacteria-expressed kinase,hydroxyaryl-protein kinase,keratinocyte growth factor receptor,protein tyrosine kinase, receptor like 14,soluble FGFR4 variant 4
- Interactome
- Related Disease
- Acrocephalosyndactylia
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- Carcinoma, Basal Cell
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- Cleft Lip
- Cleft Palate
- Craniofacial Dysostosis
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- Cystadenocarcinoma, Serous
- Depressive Disorder, Major
