Immunoprecipitation of A2M transfected lysate using anti-A2M MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with A2M purified MaxPab mouse polyclonal antibody (B01P) (H00000002-B01P).
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq