RAN recombinant monoclonal antibody, clone 15A8
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More Files
- More Functions
Immunohistochemistry
Immunohistochemistry image of RAN recombinant monoclonal antibody, clone 15A8 diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system.
Immunofluorescence
Immunofluorescence staining of Hela Cells with RAN recombinant monoclonal antibody, clone 15A8 at 1:30, counter-stained with DAPI.
Flow Cytometry
Overlay Peak curve showing Hela cells stained with RAN recombinant monoclonal antibody, clone 15A8 (red line) at 1:50.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human RAN.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to human RAN.
Reactivity
Human
Form
Liquid
Purification
Affinity chromatography purification
Isotype
IgG
Recommend Usage
ELISA
Flow Cytometry(1:50-1:200)
Immunohistochemistry(1:50-1:200)
Immunofluorescence(1:20-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150 mM NaCl, 0.02% sodium azide and 50% glycerol)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Immunohistochemistry image of RAN recombinant monoclonal antibody, clone 15A8 diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system.Immunofluorescence
Immunofluorescence staining of Hela Cells with RAN recombinant monoclonal antibody, clone 15A8 at 1:30, counter-stained with DAPI.Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
Overlay Peak curve showing Hela cells stained with RAN recombinant monoclonal antibody, clone 15A8 (red line) at 1:50. -
Gene Info — RAN
Entrez GeneID
5901Protein Accession#
P62826Gene Name
RAN
Gene Alias
ARA24, Gsp1, TC4
Gene Description
RAN, member RAS oncogene family
Omim ID
601179Gene Ontology
HyperlinkGene Summary
RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq
Other Designations
OK/SW-cl.81|RanGTPase|guanosine triphosphatase Ran|member RAS oncogene family|ras-related nuclear protein
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Interactome
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Disease
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