PRKAR2A recombinant monoclonal antibody, clone 15G8
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More Files
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Immunohistochemistry
Immunohistochemistry image of PRKAR2A recombinant monoclonal antibody, clone 15G8 diluted at 1:50 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system.
Immunofluorescence
Immunofluorescence staining of Hela Cells with PRKAR2A recombinant monoclonal antibody, clone 15G8 at 1:5, counter-stained with DAPI.
Flow Cytometry
Overlay Peak curve showing MCF-7 cells stained with PRKAR2A recombinant monoclonal antibody, clone 15G8 (red line) at 1:50.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human PRKAR2A.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to human PRKAR2A.
Reactivity
Human
Form
Liquid
Purification
Affinity chromatography purification
Isotype
IgG
Recommend Usage
ELISA
Flow Cytometry(1:50-1:200)
Immunohistochemistry(1:50-1:200)
Immunofluorescence(1:20-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150 mM NaCl, 0.02% sodium azide and 50% glycerol)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Immunohistochemistry image of PRKAR2A recombinant monoclonal antibody, clone 15G8 diluted at 1:50 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system.Immunofluorescence
Immunofluorescence staining of Hela Cells with PRKAR2A recombinant monoclonal antibody, clone 15G8 at 1:5, counter-stained with DAPI.Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
Overlay Peak curve showing MCF-7 cells stained with PRKAR2A recombinant monoclonal antibody, clone 15G8 (red line) at 1:50. -
Gene Info — PRKAR2A
Entrez GeneID
5576Protein Accession#
P13861Gene Name
PRKAR2A
Gene Alias
MGC3606, PKR2, PRKAR2
Gene Description
protein kinase, cAMP-dependent, regulatory, type II, alpha
Omim ID
176910Gene Ontology
HyperlinkGene Summary
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq
Other Designations
cAMP-dependent protein kinase regulatory subunit RII alpha|cAMP-dependent protein kinase, regulatory subunit alpha 2|protein kinase A, RII-alpha subunit
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Interactome
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Pathway
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Disease
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