ABCC2 recombinant monoclonal antibody, clone R07-4A3
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human ABCC2.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to human ABCC2.
Theoretical MW (kDa)
Calculated MW: 174 k
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Flow Cytometry (1:50-1:100)
Immunofluorescence(1:50-1:200)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end use.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol and 0.02% Sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunofluorescence
Flow Cytometry
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Gene Info — ABCC2
Entrez GeneID
1244Gene Name
ABCC2
Gene Alias
ABC30, CMOAT, DJS, KIAA1010, MRP2, cMRP
Gene Description
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq
Other Designations
OTTHUMP00000020267|canalicular multispecific organic anion transporter
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Interactome
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Disease
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