PROC recombinant monoclonal antibody, clone R06-9G8
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human PROC.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against protein corresponding to full length human PROC.
Theoretical MW (kDa)
Calculated MW: 52 kD
Reactivity
Human
Form
Liquid
Purification
Affinity chromatography
Isotype
IgG
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end use.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol and 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
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Gene Info — PROC
Entrez GeneID
5624Protein Accession#
P04070Gene Name
PROC
Gene Alias
PC, PROC1
Gene Description
protein C (inactivator of coagulation factors Va and VIIIa)
Omim ID
176860Gene Ontology
HyperlinkGene Summary
The PROC gene encodes protein C (EC 3.4.21.69), a vitamin K-dependent plasma glycoprotein that is a key component of the anticoagulant system. Protein C is cleaved to its activated form, 'activated protein C' (APC) on endothelial cells by the thrombin-thrombomodulin complex (MIM 176930; MIM 188040) and then acts as a serine protease to degrade the activated forms of coagulation factors V (F5; MIM 612309) and VIII (F8; see MIM 306700). Protein S (PROS1; MIM 176880), also a vitamin K-dependent plasma protein, functions as a cofactor to activated protein C.[supplied by OMIM
Other Designations
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Interactome
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Pathway
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Disease
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