CHD3 recombinant monoclonal antibody, clone R05-6G3
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human, mouse and rat CHD3.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against protein corresponding to full length human CHD3.
Theoretical MW (kDa)
Calculated MW: 227 k
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Affinity chromatography
Isotype
IgG
Recommend Usage
Flow Cytometry (1:50-1:100)
Immunohistochemistry (1:50-1:100)
Immunofluorescence(1:50-1:200)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end use.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol and 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
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Gene Info — CHD3
Entrez GeneID
1107Protein Accession#
Q12873Gene Name
CHD3
Gene Alias
Mi-2a, Mi2-ALPHA, ZFH
Gene Description
chromodomain helicase DNA binding protein 3
Omim ID
602120Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq
Other Designations
zinc-finger helicase (Snf2-like)
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