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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunoprecipitation

Entrez GeneID

Protein Accession#

Gene Name

ATP6V1A

Gene Alias

ATP6A1, ATP6V1A1, HO68, VA68, VPP2, Vma1

Gene Description

ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A

Omim ID

Gene Ontology

Gene Summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq

Other Designations

ATPase, H+ transporting, lysosomal 70kD, V1 subunit A, isoform 1|ATPase, H+ transporting, lysosomal, alpha polypeptide, 70kD, isoform 1|ATPase, H+ transporting, lysosomal, subunit A1|H(+)-transporting two-sector ATPase, subunit A|H+-transporting ATPase ch