APBB1 recombinant monoclonal antibody, clone R02-2T2
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human APBB1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against corresponding to human APBB1.
Theoretical MW (kDa)
Calculated MW: 77 kD
Reactivity
Human
Form
Liquid
Isotype
IgG
Recommend Usage
Immunofluorescence (1/50-1/200)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1/50-1/100)
Western Blot (1/500-1/1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol and 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunofluorescence
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Gene Info — APBB1
Entrez GeneID
322Gene Name
APBB1
Gene Alias
FE65, MGC:9072, RIR
Gene Description
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
Omim ID
602709Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants have been described for this gene but some of their full length sequence is not known. [provided by RefSeq
Other Designations
adaptor protein FE65a2|amyloid beta A4 precursor protein-binding, family B, member 1|stat-like protein
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Interactome
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Disease
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