P4HB recombinant monoclonal antibody, clone R08-6I8
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of K562, C6 lysates with P4HB recombinant monoclonal antibody, clone R08-6I8 (Cat # RAB04892).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human P4HB.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to human P4HB.
Theoretical MW (kDa)
57
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM Tris-Glycine, pH 7.4 (0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of K562, C6 lysates with P4HB recombinant monoclonal antibody, clone R08-6I8 (Cat # RAB04892). -
Gene Info — P4HB
Entrez GeneID
5034Protein Accession#
P07237Gene Name
P4HB
Gene Alias
DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB
Gene Description
prolyl 4-hydroxylase, beta polypeptide
Omim ID
176790Gene Ontology
HyperlinkGene Summary
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq
Other Designations
collagen prolyl 4-hydroxylase beta|glutathione-insulin transhydrogenase|procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide|prolyl 4-hydroxylase, beta subunit|protein disulfide isomerase family A, member 1|protein d
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Interactome
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Disease
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