LDLR recombinant monoclonal antibody, clone 2B10
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More Files
- More Functions
Immunohistochemistry
Immunohistochemical staining of human liver tissue with LDLR recombinant monoclonal antibody, clone 2B10 (Cat # RAB04391) (diluated at 1:100).
Immunohistochemistry
Immunohistochemical staining of human adrenal gland tissue with LDLR recombinant monoclonal antibody, clone 2B10 (Cat # RAB04391) (diluated at 1:100).
Immunofluorescence
Immunofluorescent staining of Hela cells with LDLR recombinant monoclonal antibody, clone 2B10 (Cat # RAB04391) (diluated at 1:50). The secondary antibody was Alexa Fluor 488-congugated goat anti-rabbit IgG (green). Counter-stain DAPI was used (blue).
Flow Cytometry
Flow cytometric analysis of HeLa cells with LDLR recombinant monoclonal antibody, clone 2B10 (Cat # RAB04391) (diluated at 1:50; purple line) and negative control (green line).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human LDLR.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to human LDLR.
Reactivity
Human
Form
Liquid
Purification
Affinity chromatography
Isotype
IgG
Recommend Usage
ELISA
Flow Cytometry (1:20-1:200)
Immunofluorescence (1:20-1:200)
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150 mM NaCl, 50% glycerol and 0.02% sodium azide)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Immunohistochemical staining of human liver tissue with LDLR recombinant monoclonal antibody, clone 2B10 (Cat # RAB04391) (diluated at 1:100).Immunohistochemistry
Immunohistochemical staining of human adrenal gland tissue with LDLR recombinant monoclonal antibody, clone 2B10 (Cat # RAB04391) (diluated at 1:100).Immunofluorescence
Immunofluorescent staining of Hela cells with LDLR recombinant monoclonal antibody, clone 2B10 (Cat # RAB04391) (diluated at 1:50). The secondary antibody was Alexa Fluor 488-congugated goat anti-rabbit IgG (green). Counter-stain DAPI was used (blue).Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
Flow cytometric analysis of HeLa cells with LDLR recombinant monoclonal antibody, clone 2B10 (Cat # RAB04391) (diluated at 1:50; purple line) and negative control (green line). -
Gene Info — LDLR
Entrez GeneID
3949Protein Accession#
P01130Gene Name
LDLR
Gene Alias
FH, FHC
Gene Description
low density lipoprotein receptor
Gene Ontology
HyperlinkGene Summary
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. [provided by RefSeq
Other Designations
LDL receptor|low-density lipoprotein receptor class A domain-containing protein 3
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Interactome
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Pathway
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Disease
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