MYC (phospho T58/S62) recombinant monoclonal antibody, clone 4E9
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More Files
- More Functions
Western Blot
Western blot analysis of Lane 1: HepG2 whole cell lysate (treated with EGF 100 ng/mL/20 mins) and Lane 2: HepG2 whole cell lysate (not treated) with MYC (phospho T58/S62) recombinant monoclonal antibody, clone 4E9 (Cat # RAB04227).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human MYC.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic phosphopeptide corresponding to residues surrounding T58/S62 of human MYC.
Theoretical MW (kDa)
Calculated MW: 57 kD
Reactivity
Human
Form
Liquid
Purification
Affinity chromatography
Isotype
IgG
Recommend Usage
ELISA
Western Blot (1:500-1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150mM NaCl, 50% glycerol and 0.02% sodium azide)
Storage Instruction
store at -20 °C or -80 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Lane 1: HepG2 whole cell lysate (treated with EGF 100 ng/mL/20 mins) and Lane 2: HepG2 whole cell lysate (not treated) with MYC (phospho T58/S62) recombinant monoclonal antibody, clone 4E9 (Cat # RAB04227).Enzyme-linked Immunoabsorbent Assay
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Gene Info — MYC
Entrez GeneID
4609Protein Accession#
P01106Gene Name
MYC
Gene Alias
bHLHe39, c-Myc
Gene Description
v-myc myelocytomatosis viral oncogene homolog (avian)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq
Other Designations
avian myelocytomatosis viral oncogene homolog|myc proto-oncogene protein|v-myc avian myelocytomatosis viral oncogene homolog
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Interactome
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Pathway
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Disease
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