GRB2 recombinant monoclonal antibody, clone 6E1
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human, mouse and rat GRB2.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to full length human GRB2.
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Affinity-chromatography
Isotype
IgG
Recommend Usage
ELISA
Immunohistochemistry (1:50-1:200)
Western Blot (1:500-1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150 mM NaCl, 50% glycerol and 0.02% sodium azide)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of Lane 1: Hela whole cell lysate; Lane 2: MCF-7 whole cell lysate; Lane 3: Mouse Brain whole cell lysate; Lane 4: Rat Brain whole cell lysate.Immunohistochemistry
Immunohistochemistry image of GRB2 recombinant monoclonal antibody, clone 6E1 diluted at 1:100 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system.Enzyme-linked Immunoabsorbent Assay
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Gene Info — GRB2
Entrez GeneID
2885Protein Accession#
P62993Gene Name
GRB2
Gene Alias
ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084
Gene Description
growth factor receptor-bound protein 2
Omim ID
108355Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
HT027|OTTHUMP00000166096|OTTHUMP00000166097|OTTHUMP00000166098|abundant SRC homology|epidermal growth factor receptor-binding protein GRB2|growth factor receptor-bound protein 3
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