SMC1A recombinant monoclonal antibody, clone 8C11
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More Files
- More Functions
Western Blot
Western Blot analysis of Lane 1: Hela whole cell lysate; Lane 2: K562 whole cell lysate; Lane 3: 293T whole cell lysate; Lane 4: Jurkat whole cell lysate; Lane 5: A549 whole cell lysate; Lane 6: HL60 whole cell lysate; Lane 7: MCF-7 whole cell lysate.
Immunohistochemistry
Immunohistochemistry image of SMC1A recombinant monoclonal antibody, clone 8C11 diluted at 1:100 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human SMC1A.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to full length human SMC1A.
Reactivity
Human
Form
Liquid
Purification
Affinity-chromatography
Isotype
IgG
Recommend Usage
ELISA
Immunohistochemistry (1:50-1:200)
Western Blot (1:500-1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150mM NaCl, 50% glycerol and 0.02% sodium azide)
Storage Instruction
store at -20 °C or -80 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of Lane 1: Hela whole cell lysate; Lane 2: K562 whole cell lysate; Lane 3: 293T whole cell lysate; Lane 4: Jurkat whole cell lysate; Lane 5: A549 whole cell lysate; Lane 6: HL60 whole cell lysate; Lane 7: MCF-7 whole cell lysate.Immunohistochemistry
Immunohistochemistry image of SMC1A recombinant monoclonal antibody, clone 8C11 diluted at 1:100 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SMC1A
Entrez GeneID
8243Protein Accession#
Q14683Gene Name
SMC1A
Gene Alias
CDLS2, DKFZp686L19178, DXS423E, KIAA0178, MGC138332, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB
Gene Description
structural maintenance of chromosomes 1A
Gene Ontology
HyperlinkGene Summary
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeq
Other Designations
OTTHUMP00000061876|SMC1 (structural maintenance of chromosomes 1, yeast)-like 1|SMC1 structural maintenance of chromosomes 1-like 1|segregation of mitotic chromosomes 1
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Interactome
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Pathway
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Disease
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