AIFM1 recombinant monoclonal antibody, clone 4B2
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human AIFM1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to full length human AIFM1.
Reactivity
Human
Form
Liquid
Purification
Affinity-chromatography
Isotype
IgG
Recommend Usage
ELISA
Immunohistochemistry (1:50-1:200)
Western Blot (1:500-1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150mM NaCl, 50% glycerol and 0.02% sodium azide)
Storage Instruction
store at -20 °C or -80 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of (1) Hela whole cell lysate, (2) Jurkat whole cell lysate, (3) A549 whole cell lysate, (4) HepG2 whole cell lysate, (5) MCF-7 whole cell lysate, (6) Rat liver tissue, (7) Rat kidney tissue.Immunohistochemistry
Immunohistochemistry staining in paraffin-embedded human kidney tissue.Enzyme-linked Immunoabsorbent Assay
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Gene Info — AIFM1
Entrez GeneID
9131Protein Accession#
O95831Gene Name
AIFM1
Gene Alias
AIF, MGC111425, PDCD8
Gene Description
apoptosis-inducing factor, mitochondrion-associated, 1
Omim ID
300169Gene Ontology
HyperlinkGene Summary
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Several alternative transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000024007|OTTHUMP00000024008|OTTHUMP00000024009|programmed cell death 8|programmed cell death 8 (apoptosis-inducing factor)|striatal apoptosis-inducing factor
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Interactome
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Pathway
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Disease
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