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Enzyme-linked Immunoabsorbent Assay

Flow Cytometry

Flow cytometric analysis of human peripheral blood leukocytes (PBL) with IL9 recombinant monoclonal antibody, clone MH9A4 (Cat # RAB03600).
Human PBL cells were fixed using 2% PFA and permeabilized with 0.5% Triton and stained with anti-Fluorescein IgG antibody (isotype control-black line) or the r version of RAB03600 (blue line) at a dilution of 1:100 for 1h at RT. After washing the bound antibody was detected using a goat anti-mouse IgG AlexaFluor® 488 antibody at a dilution of 1:1000 and cells analyzed using a FACSCanto flow-cytometer.

Entrez GeneID

3578

Gene Name

IL9

Gene Alias

HP40, IL-9, P40

Gene Description

interleukin 9

Omim ID

146931

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq

Other Designations

OTTHUMP00000159423|T-cell growth factor p40|homolog of mouse T cell and mast cell growth factor 40|p40 T-cell and mast cell growth factor|p40 cytokine