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Western Blot

Western blot analysis of Lane 1: human peripheral blood monocyte (untreated), Lane 2: human peripheral blood monocyte (treated with PMA/lonomycin), Lane 3: human spleen, Lane 4: human thymus, Lane 5: Jurkat cell and Lane 6: Molt4 cell with IL2 recombinant monoclonal antibody, clone LNKB-2 (Cat # RAB03577).
Western Blot analysis the lysates (35ug protein in RIPA buffer) were resolved on a 15% SDS PAGE gel and blots probed with the chimeric r version of RAB03577 at 1 ug/mL (Lane 1-2) or 0.1 ug/mL (Lane 3-6)before detection using an anti-rondary antibody. Protein was detected by chemiluminescence.

Immunofluorescence

Immunoprecipitation

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

3558

Gene Name

IL2

Gene Alias

IL-2, TCGF, lymphokine

Gene Description

interleukin 2

Omim ID

147680

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq

Other Designations

T cell growth factor|aldesleukin|interleukin-2|involved in regulation of T-cell clonal expansion