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Western Blot

Immunohistochemistry

Enzyme-linked Immunoabsorbent Assay

Flow Cytometry

Flow cytometric analysis of human peripheral blood leukocytes with IL16 recombinant monoclonal antibody, clone 14.1 (Cat # RAB03564).
The human peripheral blood leukocytes were fixed using 2% PFA and permeabilized 0.5% Triton and stained with anti-Fluorescein IgG antibody (isotype control-black line) or the r version of RAB03564 (blue line) at a dilution of 1:100 for 1h at RT. The blue line shows unstimulated human peripheral blood leukocytes stained with RAB03564. After washing the bound antibody was detected using a goat anti-mouse IgG AlexaFluor® 488 antibody at a dilution of 1:1000 and cells analyzed using a FACSCanto flow-cytometer.

Entrez GeneID

3603

Gene Name

IL16

Gene Alias

FLJ16806, FLJ42735, FLJ44234, HsT19289, IL-16, LCF, prIL-16

Gene Description

interleukin 16 (lymphocyte chemoattractant factor)

Omim ID

603035

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

OTTHUMP00000190849|OTTHUMP00000190850|interleukin 16|lymphocyte chemoattractant factor