DDR1 recombinant monoclonal antibody, clone 3E3
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Specification
Product Description
Mouse recombinant monoclonal antibody raised against human DDR1.
Antibody Species
Mouse
Immunogen
Original antibody is raised against the extracellular domain of human DDR1.
Reactivity
Human
Form
Liquid
Isotype
IgG1 kappa
Recommend Usage
Blocking
ELISA
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS with 0.02% Proclin 300
Storage Instruction
Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
Blocking
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Gene Info — DDR1
Entrez GeneID
780Gene Name
DDR1
Gene Alias
CAK, CD167, DDR, EDDR1, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE
Gene Description
discoidin domain receptor tyrosine kinase 1
Omim ID
600408Gene Ontology
HyperlinkGene Summary
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq
Other Designations
OTTHUMP00000029343|OTTHUMP00000029344|OTTHUMP00000029345|OTTHUMP00000029346|OTTHUMP00000029347|PTK3A protein tyrosine kinase 3A|cell adhesion kinase|discoidin domain receptor DDR1d|discoidin domain receptor family, member 1|discoidin receptor tyrosine kin
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Interactome
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Disease
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