CD40 recombinant monoclonal antibody, clone G28.5
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human CD40.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against human erythrocyte-rosette-negative tonsillar lymphocytes.
Reactivity
Human
Form
Liquid
Isotype
IgG kappa
Recommend Usage
Flow Cytometry
Immunohistochemistry
Immunoprecipitation
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% Proclin 300)
Storage Instruction
Store at 4°C for 3 months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry
Immunoprecipitation
Flow Cytometry
Flow cytometric analysis of human lymphocytes with CD40 recombinant monoclonal antibody, clone G28.5 (Cat # RAB03271).
Human lymphocytes were stained with an isotype control (3.0- panel A) or the rmeric version of RAB03271 (panel B) at a concentration of 1 ug/ml for 30 mins at RT. After washing- bound antibody was detected using a AF488 conjugated donkey anti-ribody ( and cells analysed on a FACSCanto flow-cytometer.Flow Cytometry
Flow cytometric analysis of cynomolgus monkey lymphocytes with CD40 recombinant monoclonal antibody, clone G28.5 (Cat # RAB03271).
Cynomolgus monkey lymphocytes were stained with an isotype control (3.0- panel A) or the rmeric version of RAB03271 (panel B) at a concentration of 1 ug/ml for 30 mins at RT. After washing- bound antibody was detected using a AF488 conjugated donkey anti-ribody ( and cells analysed on a FACSCanto flow-cytometer.Flow Cytometry
Flow cytometric analysis of rhesus monkey lymphocytes with CD40 recombinant monoclonal antibody, clone G28.5 (Cat # RAB03271).
Rhesus monkey lymphocytes were stained with an isotype control (3.0- panel A) or the rmeric version of RAB03271 (panel B) at a concentration of 1 ug/ml for 30 mins at RT. After washing- bound antibody was detected using a AF488 conjugated donkey anti-ribody ( and cells analysed on a FACSCanto flow-cytometer. -
Gene Info — CD40
Entrez GeneID
958Gene Name
CD40
Gene Alias
Bp50, CDW40, MGC9013, TNFRSF5, p50
Gene Description
CD40 molecule, TNF receptor superfamily member 5
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
B cell surface antigen CD40|B cell-associated molecule|CD40 antigen|CD40 antigen (TNF receptor superfamily member 5)|CD40 type II isoform|CD40L receptor|OTTHUMP00000031699|OTTHUMP00000031700|nerve growth factor receptor-related B-lymphocyte activation mol
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