AURKA/AURKB/AURKC recombinant monoclonal antibody, clone AuroraABC-CC12 (FITC)
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More Files
- More Functions
Flow Cytometry
Flow cytometric analysis of HeLa cells untreated and unstained as negative control (blue) or untreated (red) or treated with nocodazole (green) and stained using Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) antibody FITC conjugate, AuroraABC-CC12.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human AURKA/AURKB/AURKC.
Antibody Species
Rabbit
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding human Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198)
Reactivity
Human
Form
Liquid
Conjugation
FITC
Purification
Protein A purification, Protein G purification
Isotype
IgG
Recommend Usage
Flow Cytometry
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% Sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of HeLa cells untreated and unstained as negative control (blue) or untreated (red) or treated with nocodazole (green) and stained using Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) antibody FITC conjugate, AuroraABC-CC12. -
Gene Info — AURKAPS1
Entrez GeneID
6791Protein Accession#
O14965;Q96GD4;Q9UQB9Gene Name
AURKAPS1
Gene Alias
AurAps1, STK6P
Gene Description
aurora kinase A pseudogene 1
Gene Ontology
HyperlinkOther Designations
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Gene Info — AURKC
Entrez GeneID
6795Protein Accession#
O14965;Q96GD4;Q9UQB9Gene Name
AURKC
Gene Alias
AIE2, AIK3, AurC, STK13, aurora-C
Gene Description
aurora kinase C
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
aurora/IPL1-related kinase 3|aurora/IPL1/EG2 protein 2|serine/threonine kinase 13 (aurora/IPL1-like)
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Gene Info — AURKB
Entrez GeneID
9212Protein Accession#
O14965;Q96GD4;Q9UQB9Gene Name
AURKB
Gene Alias
AIK2, AIM-1, AIM1, ARK2, AurB, IPL1, STK12, STK5
Gene Description
aurora kinase B
Omim ID
604970Gene Ontology
HyperlinkGene Summary
Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al., 2004 [PubMed 14767480]).[supplied by OMIM
Other Designations
aurora-1|aurora-B|serine/threonine kinase 12
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Interactome
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Disease
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