BLNK recombinant monoclonal antibody, clone BLNKY84-H4 (FITC)
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More Files
- More Functions
Flow Cytometry
Flow cytometric analysis of Ramos cells, unstained and untreated cells as negative control (blue) or untreated (red) or treated with INFa+IL-4 + pervanadate (green) and stained using Phospho-BLNK (Tyr84) antibody BLNKY84-H4 FITCconjugate.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human BLNK.
Antibody Species
Rabbit
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr84 of human phospho BLNK
Reactivity
Human
Form
Liquid
Conjugation
FITC
Purification
Protein A purification, Protein G purification
Isotype
IgG
Recommend Usage
Flow Cytometry
The optimal working dilution should be determined by the end user.Storage Buffer
1X PBS, 0.09% Sodium azide, 0.2% BSA
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of Ramos cells, unstained and untreated cells as negative control (blue) or untreated (red) or treated with INFa+IL-4 + pervanadate (green) and stained using Phospho-BLNK (Tyr84) antibody BLNKY84-H4 FITCconjugate. -
Gene Info — BLNK
Entrez GeneID
29760Protein Accession#
Q8WV28Gene Name
BLNK
Gene Alias
BASH, BLNK-S, LY57, MGC111051, SLP-65, SLP65
Gene Description
B-cell linker
Omim ID
604515Gene Ontology
HyperlinkGene Summary
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
B cell linker protein|B-cell adapter containing a SH2 domain protein|B-cell adapter containing a Src homology 2 domain protein|OTTHUMP00000020167|Src homology 2 domain-containing leukocyte protein of 65 kDa
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Interactome
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Pathway
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Disease
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