STAT5A/STAT5B recombinant monoclonal antibody, clone Stat5Y694-B5
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More Files
- More Functions
Flow Cytometry
Flow cytometric analysis of Ramos cells untreated (red) or treated with IFNa+IL-4+ pervanadate (green) using Phospho-Stat5(Tyr694) antibody at 0.05 ug/mL, Stat5Y694-B5, or concentration-matched rabbit (G9) mAb IgG Isotype for cells untreated (black) or treated with IFNa+IL-4+pervanadate (blue).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human STAT5A|STAT5B.
Antibody Species
Rabbit
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr694 of human phospho Stat5
Reactivity
Human
Form
Liquid
Purification
Protein A+G
Isotype
Rabbit IgG1k
Recommend Usage
Flow Cytometry
The optimal working dilution should be determined by the end user.Storage Buffer
1X PBS, 0.02% Sodium azide, 50% Glycerol, 0.1% BSA
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of Ramos cells untreated (red) or treated with IFNa+IL-4+ pervanadate (green) using Phospho-Stat5(Tyr694) antibody at 0.05 ug/mL, Stat5Y694-B5, or concentration-matched rabbit (G9) mAb IgG Isotype for cells untreated (black) or treated with IFNa+IL-4+pervanadate (blue). -
Gene Info — STAT5A
Entrez GeneID
6776Protein Accession#
P42229|P51692Gene Name
STAT5A
Gene Alias
MGF, STAT5
Gene Description
signal transducer and activator of transcription 5A
Omim ID
601511Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. [provided by RefSeq
Other Designations
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Gene Info — STAT5B
Entrez GeneID
6777Protein Accession#
P42229|P51692Gene Name
STAT5B
Gene Alias
STAT5
Gene Description
signal transducer and activator of transcription 5B
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq
Other Designations
transcription factor STAT5B
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Interactome
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Pathway
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Disease
- Asthma
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