HMGCR recombinant monoclonal antibody
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human HMGCR.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against KLH conjugated synthetic peptide derived from human HMGCR.
Theoretical MW (kDa)
97
Reactivity
Human
Specificity
This antibody detects endogenous levels of HMGCR protein.
Form
Liquid
Purification
Protein A purification
Isotype
IgG
Recommend Usage
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 0.01M TBS, pH7.4 (1% BSA, 0.03% Proclin300 and 50% Glycerol)
Storage Instruction
Store at 4°C short term.
Aliquot and store at -20°C long term.
Avoid freeze-thaw cycles. -
Applications
Western Blot (Cell lysate)
Western blot analysis with HMGCR recombinant monoclonal antibody (Cat # RAB02643) at 1:1000 dilution. -
Gene Info — HMGCR
Entrez GeneID
3156Protein Accession#
P04035Gene Name
HMGCR
Gene Alias
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Gene Description
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Omim ID
142910Gene Ontology
HyperlinkGene Summary
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
3-hydroxy-3-methylglutaryl CoA reductase (NADPH)|hydroxymethylglutaryl-CoA reductase
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