CASP4 recombinant monoclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of C6 (A), NIH3T3 (B), Hela (C) whole cell lysates with Caspase 4 recombinant monoclonal antibody (Cat # RAB02477).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human CASP4.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein of mouse Caspase-11.
Theoretical MW (kDa)
45
Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of Caspase 4 protein.
Form
Liquid
Purification
Immunogen affinity chromatography
Isotype
IgG
Recommend Usage
Immunoprecipitation(1:10-1:50)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50mM Tris-Glycine, pH 7.4 (0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C short term.
Aliquot and store at -20°C long term.
Avoid freeze-thaw cycles.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of C6 (A), NIH3T3 (B), Hela (C) whole cell lysates with Caspase 4 recombinant monoclonal antibody (Cat # RAB02477).Immunoprecipitation
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Gene Info — CASP4
Entrez GeneID
837Protein Accession#
P49662Gene Name
CASP4
Gene Alias
ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX
Gene Description
caspase 4, apoptosis-related cysteine peptidase
Omim ID
602664Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
apoptotic cysteine protease Mih1/TX|caspase 4|caspase 4, apoptosis-related cysteine protease
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Interactome
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Disease
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