AXIN2 recombinant monoclonal antibody
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human AXIN2.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide of human Axin 2.
Theoretical MW (kDa)
95
Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of Axin-2 protein.
Form
Liquid
Purification
Immunogen affinity chromatography
Isotype
IgG
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50mM Tris-Glycine, pH 7.4 (0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C short term.
Aliquot and store at -20°C long term.
Avoid freeze-thaw cycles.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of K562 (A), C6 (B), NIH3T3 (C), Hela (D) whole cell lysates with Axin-2 recombinant monoclonal antibody (Cat # RAB02473). -
Gene Info — AXIN2
Entrez GeneID
8313Protein Accession#
Q9Y2T1Gene Name
AXIN2
Gene Alias
AXIL, DKFZp781B0869, MGC10366, MGC126582
Gene Description
axin 2
Gene Ontology
HyperlinkGene Summary
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq
Other Designations
conductin
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Interactome
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Pathway
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Disease
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