KRIT1 recombinant monoclonal antibody, clone R01-6K9
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More Files
- More Functions
Western Blot
Western Blot analysis of Lane 1: C6, Lane 2: 3T3, Lane 3: Hela and Lane 4: K562 lysates with KRIT1 recombinant monoclonal antibody, clone R01-6K9 (Cat # RAB02147).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human KRIT1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to human KRIT1.
Theoretical MW (kDa)
Calculated MW: 84 kD
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM Tris-Glycine, pH 7.4 (0.15 M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at -20 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of Lane 1: C6, Lane 2: 3T3, Lane 3: Hela and Lane 4: K562 lysates with KRIT1 recombinant monoclonal antibody, clone R01-6K9 (Cat # RAB02147). -
Gene Info — KRIT1
Entrez GeneID
889Protein Accession#
O00522Gene Name
KRIT1
Gene Alias
CAM, CCM1
Gene Description
KRIT1, ankyrin repeat containing
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq
Other Designations
ankyrin repeat-containing protein Krit1|cerebral cavernous malformations 1|krev interaction trapped 1
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Interactome
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Disease
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