NFATC1 (phospho Ser237) recombinant monoclonal antibody, clone R03-6I1
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More Files
- More Functions
Western Blot
Western blot analysis of Lane 1: K562 and Lane 2: 3T3 lysates with NFATC1 (phospho Ser237) recombinant monoclonal antibody, clone R03-6I1 (Cat # RAB02064).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human NFATC1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic phosphopeptide corresponding to residues surrounding Ser237 of human NFATC1.
Theoretical MW (kDa)
Calculated MW: 101 k
Reactivity
Human, Mouse
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM Tris-Glycine, pH 7.4 (0.15 M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at -20 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Lane 1: K562 and Lane 2: 3T3 lysates with NFATC1 (phospho Ser237) recombinant monoclonal antibody, clone R03-6I1 (Cat # RAB02064). -
Gene Info — NFATC1
Entrez GeneID
4772Protein Accession#
O95644Gene Name
NFATC1
Gene Alias
MGC138448, NF-ATC, NFAT2, NFATc
Gene Description
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Omim ID
600489Gene Ontology
HyperlinkGene Summary
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq
Other Designations
NFAT transcription complex cytosolic component|nuclear factor of activated T-cells, cytosolic component 1
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Interactome
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Pathway
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Disease
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