Products

Western Blot

Western blot analysis of Lane 1: A549, Lane 2: U2OS and Lane 3: C6 lysates with SMAD1 (phospho Ser463/Ser465) recombinant monoclonal antibody, clone R07-4A3 (Cat # RAB01776).

Immunoprecipitation

Entrez GeneID

4086

Protein Accession#

Q15797

Gene Name

SMAD1

Gene Alias

BSP1, JV4-1, JV41, MADH1, MADR1

Gene Description

SMAD family member 1

Omim ID

601595

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq

Other Designations

MAD, mothers against decapentaplegic homolog 1|Mad-related protein 1|SMAD, mothers against DPP homolog 1|Sma- and Mad-related protein 1|TGF-beta signaling protein 1|mothers against DPP homolog 1|transforming growth factor-beta signaling protein 1