OPTN recombinant monoclonal antibody, clone R01-2C5
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More Files
- More Functions
Western Blot
Western Blot analysis of Hela, A549, HL-60, U2OS, U87-MG lysates with OPTN recombinant monoclonal antibody, clone R01-2C5 (Cat # RAB01394).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cholangiocarcinoma with OPTN recombinant monoclonal antibody, clone R01-2C5 (Cat # RAB01394).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human OPTN.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to human OPTN.
Theoretical MW (kDa)
Calculated MW: 66 kD
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In 50mM Tris-Glycine, pH 7.4, (0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C. For longer storage, aliquot and store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of Hela, A549, HL-60, U2OS, U87-MG lysates with OPTN recombinant monoclonal antibody, clone R01-2C5 (Cat # RAB01394).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cholangiocarcinoma with OPTN recombinant monoclonal antibody, clone R01-2C5 (Cat # RAB01394). -
Gene Info — OPTN
Entrez GeneID
10133Protein Accession#
Q96CV9Gene Name
OPTN
Gene Alias
FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP
Gene Description
optineurin
Gene Ontology
HyperlinkGene Summary
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq
Other Designations
Huntingtin interacting protein L|OTTHUMP00000019125|OTTHUMP00000019126|OTTHUMP00000019127|OTTHUMP00000019128|glaucoma 1, open angle, E (adult-onset)|nemo-related protein|transcrption factor IIIA-interacting protein|tumor necrosis factor alpha-inducible ce
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Interactome
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Disease
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