XBP1 recombinant monoclonal antibody, clone R04-3E2
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot
Western blot analysis of XBP1 in Raw264.7 lysates using XBP1 antibody.
-
Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human XBP1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to human XBP1.
Theoretical MW (kDa)
Calculated MW: 29 kD
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunoprecipitation
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In 50mM Tris-Glycine, pH 7.4, (0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C. For longer storage, aliquot and store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot
Western blot analysis of XBP1 in Raw264.7 lysates using XBP1 antibody.Immunoprecipitation
-
Gene Info — XBP1
Entrez GeneID
7494Protein Accession#
P17861Gene Name
XBP1
Gene Alias
TREB5, XBP2
Gene Description
X-box binding protein 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq
Other Designations
OTTHUMP00000028682|X-box-binding protein-1
-
Interactome
-
Disease
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com