CCR4 recombinant monoclonal antibody, clone KW-0761 (Mogamulizumab)
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More Files
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Western Blot
Western Blot analysis of Human brain cerebellum lysates (35 ug protein in RIPA buffer) were resolved on a 10% SDS PAGE gel and blots probed with the chimeric rabbit IgG version of KW-0761 at 2 ug/mL before detection using an anti-rabbit secondary antibody. A primary incubation of 1h was used and protein was detected by chemiluminescence. The expected running size for CCR4 is 37.7kDa.
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Specification
Product Description
Mouse recombinant monoclonal antibody raised against human CCR4.
Antibody Species
Mouse
Immunogen
Original antibody is raised against by humanization of a mouse anti-CCR4 mAb.
Reactivity
Human
Specificity
This antibody is specific for human CCR4, a chemokine receptor that is preferentially expressed by Th2 and regulatory T (Treg) cells. CCR4 is also detected on basophils, platelets, monocytes and brain microvascular and coronary artery endothelial cells.
Form
Liquid
Purification
Protein A affinity purification
Isotype
IgG2a, Kappa
Recommend Usage
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS with 0.02% Proclin 300
Storage Instruction
Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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Applications
Western Blot
Western Blot analysis of Human brain cerebellum lysates (35 ug protein in RIPA buffer) were resolved on a 10% SDS PAGE gel and blots probed with the chimeric rabbit IgG version of KW-0761 at 2 ug/mL before detection using an anti-rabbit secondary antibody. A primary incubation of 1h was used and protein was detected by chemiluminescence. The expected running size for CCR4 is 37.7kDa. -
Gene Info — CCR4
Entrez GeneID
1233Protein Accession#
P51679Gene Name
CCR4
Gene Alias
CC-CKR-4, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5, MGC88293
Gene Description
chemokine (C-C motif) receptor 4
Omim ID
604836Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq
Other Designations
chemokine (C-C) receptor 4
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Interactome
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Pathway
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Disease
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