ITGAM recombinant monoclonal antibody, clone 107
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Specification
Product Description
Mouse recombinant monoclonal antibody raised against human ITGAM.
Antibody Species
Mouse
Immunogen
Original antibody is raised against recombinant protein corresponding to wild type human ITGAM.
Reactivity
Human
Specificity
This antibody binds to the MIDAS face of the A domain from ITGAM.
Form
Liquid
Purification
Protein A affinity purification
Isotype
IgG1, kappa
Recommend Usage
ELISA (0.1 ug/mL)
Flow Cytometry (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.02% Proclin 300)
Storage Instruction
Store at 4°C for up to 3 months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
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Gene Info — ITGAM
Entrez GeneID
3684Protein Accession#
P11215Gene Name
ITGAM
Gene Alias
CD11B, CR3A, MAC-1, MAC1A, MGC117044, MO1A, SLEB6
Gene Description
integrin, alpha M (complement component 3 receptor 3 subunit)
Omim ID
120980Gene Ontology
HyperlinkGene Summary
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
antigen CD11b (p170)|complement component receptor 3, alpha|integrin alpha M|macrophage antigen alpha polypeptide|neutrophil adherence receptor alpha-M subunit
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