ELOVL4 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ELOVL4.
Immunogen
A synthetic peptide corresponding to human ELOVL4.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
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Gene Info — ELOVL4
Entrez GeneID
6785Gene Name
ELOVL4
Gene Alias
ADMD, FLJ17667, FLJ92876, STGD2, STGD3
Gene Description
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
Gene Ontology
HyperlinkGene Summary
This gene encodes a membrane-bound protein which is a member of the ELO family, proteins which participate in the biosynthesis of fatty acids. Consistent with the expression of the encoded protein in photoreceptor cells of the retina, mutations and small deletions in this gene are associated with Stargardt-like macular dystrophy (STGD3) and autosomal dominant Stargardt-like macular dystrophy (ADMD), also referred to as autosomal dominant atrophic macular degeneration. [provided by RefSeq
Other Designations
OTTHUMP00000016776|Stargardt disease 3 (autosomal dominant)|elongation of very long chain fatty acids-like 4
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Interactome
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Disease
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Publication Reference
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ELOVL2 overexpression enhances triacylglycerol synthesis in 3T3-L1 and F442A cells.
Kobayashi T, Zadravec D, Jacobsson A.
FEBS Letters 2007 Jul; 581(17):3157.
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Cigarette smoking, CFH, APOE, ELOVL4, and risk of neovascular age-related macular degeneration.
DeAngelis MM, Ji F, Kim IK, Adams S, Capone A Jr, Ott J, Miller JW, Dryja TP.
Archives of Ophthalmology (Chicago, Ill.: 1960) 2007 Jan; 125(1):49.
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Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death.
Vasireddy V, Uchida Y, Salem N Jr, Kim SY, Mandal MN, Reddy GB, Bodepudi R, Alderson NL, Brown JC, Hama H, Dlugosz A, Elias PM, Holleran WM, Ayyagari R.
Human Molecular Genetics 2007 Mar; 16(5):471.
Application：IHC-P, WB-Ti, Mouse, Mouse skin.
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ELOVL2 overexpression enhances triacylglycerol synthesis in 3T3-L1 and F442A cells.
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