CASP10 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis using CASP10 polyclonal antibody at 0.5 ug/mL on HeLa (lane 1), Jurkat (lane 2), A-431 (lane 3), K-562 (lane 4) and NIH/3T3 (lane 5) whole cell lysates.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CASP10.
Immunogen
A synthetic peptide corresponding to amino acids 505-521 of human CASP10.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (0.5-1.0 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis using CASP10 polyclonal antibody at 0.5 ug/mL on HeLa (lane 1), Jurkat (lane 2), A-431 (lane 3), K-562 (lane 4) and NIH/3T3 (lane 5) whole cell lysates. -
Gene Info — CASP10
Entrez GeneID
843Gene Name
CASP10
Gene Alias
ALPS2, FLICE2, MCH4
Gene Description
caspase 10, apoptosis-related cysteine peptidase
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
FADD-like ICE2|Fas-associated death domain protein|ICE-like apoptotic protease 4|apoptotic protease MCH-4|caspase 10|caspase 10, apoptosis-related cysteine protease|interleukin-1B-converting enzyme 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Caspases: the executioners of apoptosis.
Cohen GM.
The Biochemical Journal 1997 Aug; 326 ( Pt 1):1.
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Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling.
Vincenz C, Dixit VM.
The Journal of Biological Chemistry 1997 Mar; 272(10):6578.
Application：WB-Tr, Human, HEK 293 cells.
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In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.
Fernandes-Alnemri T, Armstrong RC, Krebs J, Srinivasula SM, Wang L, Bullrich F, Fritz LC, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES.
PNAS 1996 Jul; 93(15):7464.
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Caspases: the executioners of apoptosis.
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