TPH1 (phospho S58) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of TPH1.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S58 of rabbit TPH1.
Host
Rabbit
Theoretical MW (kDa)
55
Reactivity
Bovine, Clawed frog, Dog, Human, Mouse, Primates, Rabbit, Rat, Zebra fish
Form
Liquid
Purification
Affinity purification
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM HEPES, 150 mM NaCl, pH 7.5 (50% glycerol, 10% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Recombinant protein)
Western blot of recombinant tryptophan hydroxylase incubated in the absence (Control) and presence of cAMP-dependent protein kinase (PKA) showing specific immunolabeling of the ~53k TPH1 protein phosphorylated at Ser58. -
Gene Info — TPH1
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Publication Reference
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A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosynthesis.
Martinez A, Knappskog PM, Haavik J.
Current Medicinal Chemistry 2001 Jul; 8(9):1077.
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Identification of substrate orienting and phosphorylation sites within tryptophan hydroxylase using homology-based molecular modeling.
Jiang GC, Yohrling GJ 4th, Schmitt JD, Vrana KE.
Journal of Molecular Biology 2000 Sep; 302(4):1005.
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Phosphorylation and activation of brain tryptophan hydroxylase: identification of serine-58 as a substrate site for protein kinase A.
Kuhn DM, Arthur R Jr, States JC.
Journal of Neurochemistry 1997 May; 68(5):2220.
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A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosynthesis.
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