ZBTB16 (phospho Y334) polyclonal antibody
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More Files
- More Functions
Dot Blot (Peptide)
Dot blot analysis of ZBTB16 (phospho Y334) polyclonal antibody (Cat # PAB8181) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 ug/mL.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of ZBTB16.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y334 of human ZBTB16.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
ELISA (1:1000)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
Dot Blot (Peptide)
Dot blot analysis of ZBTB16 (phospho Y334) polyclonal antibody (Cat # PAB8181) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 ug/mL. -
Gene Info — ZBTB16
Entrez GeneID
7704Protein Accession#
NP_005997;Q05516Gene Name
ZBTB16
Gene Alias
PLZF, ZNF145
Gene Description
zinc finger and BTB domain containing 16
Omim ID
176797Gene Ontology
HyperlinkGene Summary
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq
Other Designations
Kruppel-like zinc finger protein|promyelocytic leukemia zinc finger protein|zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)
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Interactome
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Pathway
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Disease
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Publication Reference
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A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis.
Labbaye C, Spinello I, Quaranta MT, Pelosi E, Pasquini L, Petrucci E, Biffoni M, Nuzzolo ER, Billi M, Foa R, Brunetti E, Grignani F, Testa U, Peschle C.
Nature Cell Biology 2008 Jun; 10(7):788.
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The promyelocytic leukemia zinc finger-microRNA-221/-222 pathway controls melanoma progression through multiple oncogenic mechanisms.
Felicetti F, Errico MC, Bottero L, Segnalini P, Stoppacciaro A, Biffoni M, Felli N, Mattia G, Petrini M, Colombo MP, Peschle C, Care A.
Cancer Research 2008 Apr; 68(8):2745.
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Redox-mediated modification of PLZF by SUMO-1 and ubiquitin.
Kang SI, Choi HW, Kim IY.
Biochemical and Biophysical Research Communications 2008 May; 369(4):1209.
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A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis.
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