BDNF polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BDNF.
Immunogen
A synthetic peptide corresponding to amino acids at middle region of human BDNF.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
Identical to the related rat and mouse sequence.
Form
Lyophilized
Purification
Immunoaffinity purification
Isotype
IgG
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of human brain tissue extracts with BDNF polyclonal antibody (Cat # PAB7956). -
Gene Info — BDNF
Entrez GeneID
627Gene Name
BDNF
Gene Alias
MGC34632
Gene Description
brain-derived neurotrophic factor
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq
Other Designations
neurotrophin
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Interactome
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Pathway
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Disease
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Publication Reference
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Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters.
Pruunsild P, Kazantseva A, Aid T, Palm K, Timmusk T.
Genomics 2007 Sep; 90(3):397.
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Regulation of cell survival by secreted proneurotrophins.
Lee R, Kermani P, Teng KK, Hempstead BL.
Science 2001 Nov; 294(5548):1495.
Application:WB-Ce, WB-Tr, Human, Mouse, HEK 293, Murine endothelial cells.
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Molecular cloning of a human gene that is a member of the nerve growth factor family.
Jones KR, Reichardt LF.
PNAS 1990 Oct; 87(20):8060.
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Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters.
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