CRHR1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CRHR1.
Immunogen
A synthetic peptide corresponding to amino acids 107-117 of human CRHR1.
Sequence
C-NEEKKSKVHYH
Host
Goat
Theoretical MW (kDa)
47.7
Reactivity
Human, Mouse
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
CRHR1 polyclonal antibody (Cat # PAB7539) (0.1 ug/mL) staining of human colon lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunofluorescence
Confocal image (3 ug/mL) of CRHR1 polyclonal antibody (Cat # PAB7539) (0.3 ug/mL) staining in green a dendrite of a neuronal cell in C57 mouse cortex. Counter-stained with DAPI (in blue). Data kindly provided by Dr Y. Chen, TZ Baram lab, UC Irvine, CA.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CRHR1
Entrez GeneID
1394Protein Accession#
NP_004373.2Gene Name
CRHR1
Gene Alias
CRF-R, CRF1, CRFR1, CRH-R1h, CRHR, CRHR1f
Gene Description
corticotropin releasing hormone receptor 1
Omim ID
122561Gene Ontology
HyperlinkGene Summary
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants
Other Designations
CRF1 receptor isoform I variant B|corticotropin releasing hormone receptor variant 1h|corticotropin-releasing factor receptor|seven transmembrane helix receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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The Local Hypothalamic-Pituitary-Adrenal Axis in Cultured Human Dermal Papilla Cells.
Eun Young Lee, You Jin Nam, Sangjin Kang, Eun Ju Choi, Inbo Han, Jinwan Kim, Dong Hyun Kim, Ji Hae An, Sunghou Lee, Min Ho Lee, Ji Hyung Chung.
BMC molecular and cell biology 2020 Jun; 21(1):42.
Application:IF, IHC, WB, Human, Mesenchymal-derived dermal papilla, outer root sheath cells.
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Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation.
Rissman RA, Lee KF, Vale W, Sawchenko PE.
Journal of Neuroscience 2007 Jun; 27(24):6552.
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The Local Hypothalamic-Pituitary-Adrenal Axis in Cultured Human Dermal Papilla Cells.
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