DUOX1 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
DUOX1 polyclonal antibody (Cat # PAB7468) (4 ug/mL) staining of paraffin embedded human thyroid gland. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of DUOX1.
Immunogen
A synthetic peptide corresponding to human DUOX1.
Sequence
EKFQRSCLHQTVQ
Host
Goat
Theoretical MW (kDa)
177
Specificity
This antibody is expected to recognize both reported isoforms (NP_059130.2 , NP_787954.1) which are identical.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
DUOX1 polyclonal antibody (Cat # PAB7468) (4 ug/mL) staining of paraffin embedded human thyroid gland. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — DUOX1
Entrez GeneID
53905Protein Accession#
NP_059130.2;NP_787954.1Gene Name
DUOX1
Gene Alias
LNOX1, MGC138840, MGC138841, NOXEF1, THOX1
Gene Description
dual oxidase 1
Omim ID
606758Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX2. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq
Other Designations
NADPH thyroid oxidase 1|flavoprotein NADPH oxidase|nicotinamide adenine dinucleotide phosphate oxidase
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Interactome
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Disease
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Publication Reference
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Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium.
Harper RW, Xu C, Eiserich JP, Chen Y, Kao CY, Thai P, Setiadi H, Wu R.
FEBS Letters 2005 Aug; 579(21):4911.
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Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium.
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