TMPRSS3 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
TMPRSS3 polyclonal antibody (Cat # PAB7409) (0.1 ug/mL) staining of A-431 cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of TMPRSS3.
Immunogen
A synthetic peptide corresponding to human TMPRSS3.
Sequence
C-EKIVYHSKYKPKR
Host
Goat
Theoretical MW (kDa)
49.4, 35.8, 37.5
Reactivity
Human
Specificity
This antibody is expected to recognize all four reported isoforms (NP_076927.1; NP_115777.1; NP_115780.1; NP_115781.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
TMPRSS3 polyclonal antibody (Cat # PAB7409) (0.1 ug/mL) staining of A-431 cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TMPRSS3
Entrez GeneID
64699Protein Accession#
NP_076927.1;NP_115777.1;NP_115780.1;NP_115781.1Gene Name
TMPRSS3
Gene Alias
DFNB10, DFNB8, ECHOS1, TADG12
Gene Description
transmembrane protease, serine 3
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, a LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq
Other Designations
OTTHUMP00000109345|serine protease TADG12
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Interactome
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Disease
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Publication Reference
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Pathogenic mutations but not polymorphisms in congenital and childhood onset autosomal recessive deafness disrupt the proteolytic activity of TMPRSS3.
Lee YJ, Park D, Kim SY, Park WJ.
Journal of Medical Genetics 2003 Aug; 40(8):629.
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Pathogenic mutations but not polymorphisms in congenital and childhood onset autosomal recessive deafness disrupt the proteolytic activity of TMPRSS3.
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