THRB polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
THRB polyclonal antibody (Cat # PAB7340) (0.3 ug/mL) staining of human bone marrow lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of THRB.
Immunogen
A synthetic peptide corresponding to human THRB.
Sequence
C-REELQKSIGHKP
Host
Goat
Theoretical MW (kDa)
52.8
Reactivity
Human
Specificity
This antibody is not expected to cross-react to THRA.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
THRB polyclonal antibody (Cat # PAB7340) (0.3 ug/mL) staining of human bone marrow lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — THRB
Entrez GeneID
7068Protein Accession#
NP_000452.2Gene Name
THRB
Gene Alias
ERBA-BETA, ERBA2, GRTH, MGC126109, MGC126110, NR1A2, PRTH, THR1, THRB1, THRB2
Gene Description
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000161044|avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2|oncogene ERBA2|thyroid hormone receptor beta 1|thyroid hormone receptor beta isoform|thyroid hormone receptor, beta
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Interactome
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Pathway
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Disease
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Publication Reference
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A newly identified insertion mutation in the thyroid hormone receptor-beta gene in a Korean family with generalized thyroid hormone resistance.
Kim JH, Park TS, Baek HS, Kim GH, Yoo HW, Park JH.
Journal of Korean Medical Science 2007 Jun; 22(3):560.
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A newly identified insertion mutation in the thyroid hormone receptor-beta gene in a Korean family with generalized thyroid hormone resistance.
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