PDE11A polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
PDE11A polyclonal antibody (Cat # PAB7327) (1 ug/mL) staining of human prostate lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PDE11A.
Immunogen
A synthetic peptide corresponding to human PDE11A.
Sequence
C-NSFKESMEKSSYSD
Host
Goat
Theoretical MW (kDa)
105, 78.1, 65.7, 55.
Reactivity
Human
Specificity
This antibody is expected to recognize all four reported isoforms (NP_058649.3 , NP_001070665.1, NP_001070826.1, NP_001070664.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:2000)
Western Blot (0.5-1.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
PDE11A polyclonal antibody (Cat # PAB7327) (1 ug/mL) staining of human prostate lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PDE11A
Entrez GeneID
50940Protein Accession#
NP_058649.3;NP_001070665.1;NP_001070826.1;NP_001070664.1Gene Name
PDE11A
Gene Alias
FLJ23693, MGC133355, MGC133356, PPNAD2
Gene Description
phosphodiesterase 11A
Gene Ontology
HyperlinkGene Summary
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
cAMP and cGMP cyclic nucleotide phosphodiesterase 11A|cyclic nucleotide phosphodiesterase 11A|dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
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Interactome
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Pathway
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Disease
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Publication Reference
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A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia.
Horvath A, Boikos S, Giatzakis C, Robinson-White A, Groussin L, Griffin KJ, Stein E, Levine E, Delimpasi G, Hsiao HP, Keil M, Heyerdahl S, Matyakhina L, Libe R, Fratticci A, Kirschner LS, Cramer K, Gaillard RC, Bertagna X, Carney JA, Bertherat J, Bossis I, Stratakis CA.
Nature Genetics 2006 Jun; 38(7):794.
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A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia.
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