CCDC50 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CCDC50.
Immunogen
A synthetic peptide corresponding to human CCDC50.
Sequence
CFSKSESSHKGFHYK
Host
Goat
Theoretical MW (kDa)
56.3, 35.8
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms of human Ymer protein.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
CCDC50 polyclonal antibody (Cat # PAB6706, 5 ug/mL) staining of paraffin embedded human pancreas. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CCDC50
Entrez GeneID
152137Protein Accession#
NP_848018.1;NP_777568.1Gene Name
CCDC50
Gene Alias
C3orf6, DFNA44, YMER
Gene Description
coiled-coil domain containing 50
Gene Ontology
HyperlinkGene Summary
This gene encodes a soluble, cytoplasmic, tyrosine-phosphorylated protein with multiple ubiquitin-interacting domains. Mutations in this gene cause nonsyndromic, postlingual, progressive sensorineural DFNA44 hearing loss. In mouse, the protein is expressed in the inner ear during development and postnatal maturation and associates with microtubule-based structures. This protein may also function as a negative regulator of NF-kB signaling and as an effector of epidermal growth factor (EGF)-mediated cell signaling. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
Ymer protein
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Interactome
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Publication Reference
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Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics.
Blagoev B, Ong SE, Kratchmarova I, Mann M.
Nature Biotechnology 2004 Sep; 22(9):1139.
Application:WB, Human, HeLa cells.
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Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics.
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