POLL polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
POLL polyclonal antibody (Cat # PAB6543, 5 ug/mL) staining of paraffin embedded human small intestine. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of POLL.
Immunogen
A synthetic peptide corresponding to human POLL.
Sequence
C-LGLPYREPAERDW
Host
Goat
Theoretical MW (kDa)
63.5
Reactivity
Human
Specificity
This antibody may crossreact with Pol beta (NP_002681), an evolutionarilly related polymerase with a predicted size of 39 KDa. The overall % of identity is not very high (about 32% in the core) but considering only the that we used as immunogen the two share the sequence YREP**R** at the C-terminus. Further the protein structures appear to be very similar in this region.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
POLL polyclonal antibody (Cat # PAB6543, 5 ug/mL) staining of paraffin embedded human small intestine. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — POLL
Entrez GeneID
27343Protein Accession#
NP_0.37406Gene Name
POLL
Gene Alias
BETA-N, FLJ46002, POL-KAPPA
Gene Description
polymerase (DNA directed), lambda
Omim ID
606343Gene Ontology
HyperlinkGene Summary
O
Other Designations
DNA polymerase kappa (DNA polymerase beta-N)|DNA polymerase lambda|DNA polymerase lamda2|OTTHUMP00000020321|OTTHUMP00000020323|OTTHUMP00000059179|polymerase (DNA-directed), lambda
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Interactome
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Pathway
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Disease
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Publication Reference
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DNA polymerase lambda, a novel DNA repair enzyme in human cells.
Garcia-Diaz M, Bebenek K, Sabariegos R, Dominguez O, Rodriguez J, Kirchhoff T, Garcia-Palomero E, Picher AJ, Juarez R, Ruiz JF, Kunkel TA, Blanco L.
The Journal of Biological Chemistry 2002 Apr; 277(15):13184.
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DNA polymerase lambda, a novel DNA repair enzyme in human cells.
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