FOXA2 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
FOXA2 polyclonal antibody (Cat # PAB6419) staining (1 ug/mL) of human liver lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of FOXA2.
Immunogen
A synthetic peptide corresponding to C-terminus of human FOXA2.
Sequence
C-GVYSRPIMNSS
Host
Goat
Theoretical MW (kDa)
48.9, 48.3
Reactivity
Human
Specificity
Both reported variants represent identical protein (NP_068556.1, NP_710141.1)
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:4000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
FOXA2 polyclonal antibody (Cat # PAB6419) staining (1 ug/mL) of human liver lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — FOXA2
Entrez GeneID
3170Protein Accession#
NP_068556.1;NP_710141.1Gene Name
FOXA2
Gene Alias
HNF3B, MGC19807, TCF3B
Gene Description
forkhead box A2
Omim ID
600288Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000030409|OTTHUMP00000030410|hepatic nuclear factor-3-beta|hepatocyte nuclear factor 3, beta
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Interactome
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Pathway
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Disease
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Publication Reference
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Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release.
Wang H, Gauthier BR, Hagenfeldt-Johansson KA, Iezzi M, Wollheim CB.
The Journal of Biological Chemistry 2002 May; 277(20):17564.
Application：IF, WB-Tr, Rat, INS-1 cells.
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Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release.
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