PMS1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PMS1.
Immunogen
A synthetic peptide corresponding to human PMS1.
Sequence
C-RPFFHHLTYLPETT
Host
Goat
Theoretical MW (kDa)
106, 101, 86.6
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — PMS1
Entrez GeneID
5378Protein Accession#
NP_000525.1Gene Name
PMS1
Gene Alias
DKFZp781M0253, FLJ98259, HNPCC3, PMSL1, hPMS1
Gene Description
PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
Omim ID
600258Gene Ontology
HyperlinkGene Summary
This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome. [provided by RefSeq
Other Designations
human homolog of yeast mutL|mismatch repair gene PMSL1|postmeiotic segregation 1|rhabdomyosarcoma antigen MU-RMS-40.10B|rhabdomyosarcoma antigen MU-RMS-40.10E
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Interactome
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Disease
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Publication Reference
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Mutations of two PMS homologues in hereditary nonpolyposis colon cancer.
Nicolaides NC, Papadopoulos N, Liu B, Wei YF, Carter KC, Ruben SM, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM, et al..
Nature 1994 Sep; 371(6492):75.
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Mutations of two PMS homologues in hereditary nonpolyposis colon cancer.
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