ELMO2 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
ELMO2 polyclonal antibody (Cat # PAB6106) staining (2 ug/mL) of human brain lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 12 hour. Detected by western blot using chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
ELMO2 polyclonal antibody (Cat # PAB6106)(3.8 ug/mL) staining of paraffin embedded human prostate. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ELMO2.
Immunogen
A synthetic peptide corresponding to C-terminus of human ELMO2.
Sequence
C-PKEPSSYDFVYHYG
Host
Goat
Theoretical MW (kDa)
82.5
Reactivity
Human
Specificity
NP_877496.1 and NP_57340.3.1 are varients that encode the same protein.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western blot (1-3 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (3-6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
ELMO2 polyclonal antibody (Cat # PAB6106) staining (2 ug/mL) of human brain lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 12 hour. Detected by western blot using chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
ELMO2 polyclonal antibody (Cat # PAB6106)(3.8 ug/mL) staining of paraffin embedded human prostate. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ELMO2
Entrez GeneID
63916Protein Accession#
NP_877496.1;NP_57340.3.1Gene Name
ELMO2
Gene Alias
CED-12, CED12, ELMO-2, FLJ11656, KIAA1834
Gene Description
engulfment and cell motility 2
Omim ID
606421Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq
Other Designations
OTTHUMP00000031762|PH domain protein CED12A|ced-12 homolog 2
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Interactome
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Disease
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Publication Reference
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CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.
Gumienny TL, Brugnera E, Tosello-Trampont AC, Kinchen JM, Haney LB, Nishiwaki K, Walk SF, Nemergut ME, Macara IG, Francis R, Schedl T, Qin Y, Van Aelst L, Hengartner MO, Ravichandran KS.
Cell 2001 Oct; 107(1):27.
Application：WB-Tr, Mouse, LR73 cells.
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CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.
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