MTM1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
The MTM1 polyclonal antibody (Cat # PAB4507) is used in Western blot to detect MTM1 in mouse heart tissue lysate .
Western Blot (Cell lysate)
The MTM1 polyclonal antibody (Cat # PAB4507) is used in Western blot to detect MTM1 in NCI-H460 cell lysate .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MTM1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human MTM1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The MTM1 polyclonal antibody (Cat # PAB4507) is used in Western blot to detect MTM1 in mouse heart tissue lysate .Western Blot (Cell lysate)
The MTM1 polyclonal antibody (Cat # PAB4507) is used in Western blot to detect MTM1 in NCI-H460 cell lysate .Enzyme-linked Immunoabsorbent Assay
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Gene Info — MTM1
Entrez GeneID
4534Protein Accession#
NP_000243;Q13496Gene Name
MTM1
Gene Alias
CNM, MTMX, XLMTM
Gene Description
myotubularin 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. It is required for muscle cell differentiation and mutations in this gene have been identified as being responsible for X-linked myotubular myopathy. [provided by RefSeq
Other Designations
myotubularin
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Interactome
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Disease
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Publication Reference
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Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP.
Nandurkar HH, Layton M, Laporte J, Selan C, Corcoran L, Caldwell KK, Mochizuki Y, Majerus PW, Mitchell CA.
PNAS 2003 Jul; 100(15):8660.
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PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease.
Wishart MJ, Dixon JE.
Trends in Cell Biology 2002 Dec; 12(12):579.
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Characterisation of mutations in 77 patients with X-linked myotubular myopathy, including a family with a very mild phenotype.
Biancalana V, Caron O, Gallati S, Baas F, Kress W, Novelli G, D'Apice MR, Lagier-Tourenne C, Buj-Bello A, Romero NB, Mandel JL.
Human Genetics 2002 Nov; 112(2):135.
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Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP.
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