KLK6 polyclonal antibody
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More Files
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Western Blot (Transfected lysate)
Western blot analysis of KLK6 (arrow) using KLK6 polyclonal antibody (Cat # PAB4413).
293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the KLK6 gene (Lane 2).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin fixed and paraffin embedded human brain was performed with KLK6 polyclonal antibody (Cat # PAB4413) at 1:10-1:50 dilution followed by indirect peroxidase conjugation with secondary antibody and DAB staining.
Flow Cytometry
Flow cytometric analysis of 293 cells (right histogram), compared to a negative control cell (left histogram), was performed with KLK6 polyclonal antibody (Cat # PAB4413) and FITC-conjugated goat-anti-rabbit secondary antibody.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of KLK6.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human KLK6.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
Immunohistochemisty (1:10-1:50)
Flow Cytometry (1:10-1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of KLK6 (arrow) using KLK6 polyclonal antibody (Cat # PAB4413).
293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the KLK6 gene (Lane 2).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin fixed and paraffin embedded human brain was performed with KLK6 polyclonal antibody (Cat # PAB4413) at 1:10-1:50 dilution followed by indirect peroxidase conjugation with secondary antibody and DAB staining.Flow Cytometry
Flow cytometric analysis of 293 cells (right histogram), compared to a negative control cell (left histogram), was performed with KLK6 polyclonal antibody (Cat # PAB4413) and FITC-conjugated goat-anti-rabbit secondary antibody. -
Gene Info — KLK6
Entrez GeneID
5653Protein Accession#
NP_002765;Q92876Gene Name
KLK6
Gene Alias
Bssp, Klk7, MGC9355, NEUROSIN, PRSS18, PRSS9, SP59, ZYME, hK6
Gene Description
kallikrein-related peptidase 6
Omim ID
602652Gene Ontology
HyperlinkGene Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq
Other Designations
kallikrein 6 (neurosin, zyme)|protease M|protease, serine, 18|protease, serine, 9
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Interactome
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Disease
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Publication Reference
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Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease.
Christophi GP, Isackson PJ, Blaber S, Blaber M, Rodriguez M, Scarisbrick IA.
Journal of Neurochemistry 2004 Dec; 91(6):1439.
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Cloning and characterization of novel isoforms of the human kallikrein 6 gene.
Pampalakis G, Kurlender L, Diamandis EP, Sotiropoulou G.
Biochemical and Biophysical Research Communications 2004 Jul; 320(1):54.
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Human kallikrein 6 activity is regulated via an autoproteolytic mechanism of activation/inactivation.
Bayes A, Tsetsenis T, Ventura S, Vendrell J, Aviles FX, Sotiropoulou G.
Biological Chemistry 2004 Jun; 385(6):517.
Application：WB-Re, Recombinant protein.
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Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease.
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